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Abbrevia: Int. J. P P. Res.

 

Language: English

 

ISSN: 2315-6361

 

DOI: 10.14412/IJPPR

 

 

 Int. J. P P. Res.

3(2): 093-106, June 2020

 View: PDF (295KB) 

 

 

 

International Journal of Pharmacy and Pharmacology Research, Vol. 3(2), pp 093-106 June 2020

doi:1014412/IJPPR2020.092

(ISSN 2315-6361) 2020 Science Park Journals

Full Length Research Paper

 

 

Synthesis, Characterization And Antibacterial Screening Of Some Novel Chalcone Derivatives  Containing  Imidazo [1,2-A]-Pyridine Moiety.

 

Vikas Dashrath Sonawane *1

 

1 Department of Chemistry, Smt. Kusumtai Rajarambapu Patil Kanya Mahavidyalaya, Islampur- 415409,  Sangli, Maharashtra, India.

 

 

 Abstract

 

A series of condensed Novel Imidazo [1,2-A] Pyridine Chalcones have been prepared  by Claisen–Schmidt condensation reaction. Novel Imidazo [1,2-A] Pyridine based chalcones were synthesized  using various substituted teralones and 3-formyl-2-phenyl-imidazo [1,2-a] pyridine  in PEG-400 as green recyclable solvent. Chalcone synthesis is carried out by forming 3-formyl-2-phenyl-imidazo [1,2-a] pyridine and then its reaction with  different substituted tetralones. The structures of these compounds were confirmed on the basis of spectral data. All the title compounds were screened for their antimicrobial activities. The screening data indicated that tested compounds showed good antimicrobial activity against B.coccus, S.aureus, Pseudomona, E.coli,and antibiotics such as A.niger, Ampicillin, Amoxicillin, Norfloxacin. Their minimum inhibitory concentrations (MIC) were determined and the compounds 5a,5b,5c and 5e shows good results of antibacterial activity against standard B.coccus, S.aureus, Pseudomona and  E.coli bacteria.

 

KEYWORDS: Antibacterial activity, PEG-400, Imidazo[1,2-A]-Pyridines Chalcones, 3-formyl-2-phenyl-imidazo[1,2-a]pyridine. 

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