The present paper focused on the intercalation
of ibuprofen into Unmodified sodium montmorillonite,
chitosan and chitosan montmorillonite
nanocomposites as a sustained release drug
carrier. The intercalation compounds were
characterized by X-ray diffraction (XRD),
Infrared spectroscopy (IR), Thermogravimetric
analysis (TGA), and transmission electron
microscopy (TEM). The basal spacing of
montmorillonite increased from 9.6 nm to 19.6 nm
as indicate of intercalation of modified
chitosan and ibuprofen between lamellar layers.
UV spectroscopy was employed to monitor the in
vitro drug release processes in both pH 5.4 and
7.8 solutions. And the experiment revealed that
Ibuprofen was released from MMT, CS and Mod-CS/MMT
steadily and pH dependent.
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