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  Sci. Res. Impact.  

  4(1): 05-019, April 2018

 

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Scientific Research and Impact, Vol. 4(1), pp 006-019 April 2018

doi:1014412/SRI2018.019

(ISSN 2315-5396) 2018 Science Park Journals

Full Length Research Paper

 

 

Modified Chitosan-Clay nanocomposite As a drug delivery system Intercalation and in vitro release of Ibuprofen.

 

Rehab Abdeen1,*, Nehal Salahuddin2

1 Associated professor, biology department, king Khalid university,

2. professor, Department of Chemistry, Polymer Research Group, Faculty of Science, Tanta University.

*Corresponding author. E-mail: salahudin.nehal@yahoo.com  

 

 Abstract

 

The present paper focused on the intercalation of ibuprofen into Unmodified sodium  montmorillonite, chitosan and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The intercalation compounds were characterized by X-ray diffraction (XRD), Infrared spectroscopy (IR), Thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 nm to 19.6 nm as indicate of intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. And the experiment  revealed that Ibuprofen was released from MMT, CS and Mod-CS/MMT  steadily and pH dependent.

 

 Keywords: Chitosan; Nanocomposite; Ibuprofen; controlled release.

 

 



 

 

                                                                                                       

 

 

          

 

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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